القيمة التشخيصية والتنبؤية للعلامات الالتهابية (l IL-6) في التنبؤ بتطور القدم السكرية لدى مرضى السكري من النوع 2 في مستشفى الوحدة

• MOHAMMED MURJIA ALI QASSIM

  Darna University ،Medicine Faculty،Surgical department، Darna, Libya

  Author

يُعد مرض القدم السكري من المضاعفات الرئيسية لمرض السكري من النوع الثاني (T2DM)، حيث يسهم الالتهاب في حدوث تلف الأنسجة وتأخر التئام الجروح. هدفت هذه الدراسة إلى تقييم مستوى الإنترلوكين-6 (IL-6) في مصل الدم باعتباره مؤشرًا حيويًا محتملًا لمرض القدم السكري وتطوره. شملت الدراسة الرصدية 120 مريضًا مصابًا بداء السكري من النوع الثاني، منهم 60 مريضًا دون الإصابة بمرض القدم السكري و60 مريضًا مصابًا به، وخضع جميع المرضى للتقييم السريري وقياس مستوى IL-6 في مصل الدم باستخدام تقنية ELISA. أظهرت النتائج أن المرضى المصابين بمرض القدم السكري لديهم مستويات أعلى بشكل ملحوظ من IL-6 مقارنةً بمجموعة الضبط (19.01 ± 5.95 مقابل 4.98 ± 2.00 بيكوغرام/مل، p < 0.001). كما وُجد ارتباط قوي بين مستوى IL-6 ومرض القدم السكري (ρ = 0.864، p < 0.001) وبين IL-6 والبروتين المتفاعل C (CRP) (r = 0.762، p < 0.001). في المقابل، لم تُظهر مستويات IL-6 فروقًا ذات دلالة إحصائية بين درجات Wagner المختلفة (p = 0.786) أو خلال فترة المتابعة التي تراوحت بين 3 و6 أشهر (p = 0.631).وأظهر تحليل منحنى ROC أداءً تشخيصيًا ممتازًا لـ IL-6، حيث بلغت المساحة تحت المنحنى (AUC = 0.999)، متفوقًا على كل من CRP (0.944) وESR (0.915) وكريات الدم البيضاء WBC (0.851). كما ارتبط ارتفاع مستويات IL-6 بوجود مرض القدم السكري في تحليل الانحدار اللوجستي (OR = 14.09، فاصل الثقة 95%: 1.29–153.88، p = 0.030). وبناءً على ذلك، قد يمثل IL-6 في مصل الدم مؤشرًا حيويًا ذا قيمة للتعرف على مرضى السكري من النوع الثاني الأكثر عرضة للإصابة بمرض القدم السكري، كما قد يسهم في التقييم المبكر لمستوى الخطورة والمساعدة في توجيه التدبير السريري والعلاجي.

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