Oncogenesis of Helicobacter pylori and Associated Colorectal Cancer

• Emhamed Ahmed Boras

  Libyan Academy of postgraduate Studies, Life Science Department, Tripoli/ Janzor

  Author

• Mohamad Alahmar

  Tripoli Ministry of Health, Tripoli Medical Center

  Author

• Sh-hoob El-ahmir

  Faculty of science, Botany Department, Gharyan University.

  Author

• Omro A. Aburas

  Higher Institute of Science and Medical Technology, Pharmacy Department, Tripoli/Abusalim.

  Author

• Noor Thamer Alsanawi

  Libyan Academy of postgraduate Studies, Life Science Department, Tripoli/ Janzor

  Author

Background and objective: Helicobacter pylori [H.pylori] infection is one of the most common chronic bacterial infections worldwide especially in the developing countries. This bacterium is the cause of many diseases such as MALT lymphoma, gastritis, peptic ulcers, and stomach cancer. According to recent reports, H.pylori infection may increase the risk of colorectal cancer. The current study aimed at investigating the association of H. pylori infection and the risk of colorectal cancer and adenomatous polyps. Methods: The current study was conducted on 52 patients with colon cancer as the case group and 200 subjects without pathological finding (i e, polyps, neoplasms, or inflammatory diseases) as the control group. Blood samples were collected from the patients in order to assess the presence of anti-H. pylori infection antibodies by the serum titer levels of anti-H. pylori IgG antibodies were measured using enzyme-linked immunosorbent assay (ELISA) with commercial kit by (Dia.Pro Diagnostic Bioprobes-Italy). Results: This study demonstrates distinct associations between H.pylori infection markers and CRC risk. While IgG seropositivity showed a significant 2.16-fold increased CRC risk (p = 0.019). Conclusion: This research finding IgG seropositivity may serve as a broader risk marker.

1. Emhamed Ahmed Boras, Libyan Academy of postgraduate Studies, Life Science Department, Tripoli/ Janzor

   Libyan Academy of postgraduate Studies, Life Science Department, Tripoli/ Janzor

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