Vitamin D Deficiency Relationship with Age and Gender
- Authors
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Fathia Eessa faid
1University of Misrata, Faculty oh Health Sciences, Nutrition Department, Misrata, LibyaAuthor -
Aziza M Agwaida Alsheekh
College of Medical Technology, Department of Lab Medicine, Derna, LibyaAuthor -
Maryam Fawzi Abais
3College of Medical Technology, General Department, Derna LibyaAuthor -
Salwa Muftah Eljamay
4College of Medical Technology, Department of Public Health, Derna, LibyaAuthor
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- Keywords:
- Vitamin D, Deficiency, Gender, Ages, Relationship
- Abstract
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Vitamin D deficiency is a widespread public health concern, influencing various physiological processes, including bone health and immune function. This cross-sectional study evaluates the relationship between Vitamin D levels, age, and gender among 1,416 individuals (708 males and 708 females). Data collection involved structured questionnaires and laboratory assessments of serum 25-hydroxyvitamin D (25(OH)D) concentrations. The results indicate a high prevalence of severe Vitamin D deficiency in both genders, affecting 238 males and 244 females. Normal Vitamin D levels were observed in 402 individuals, with a slightly higher prevalence in females. Correlation analysis revealed a weak but statistically significant negative relationship between gender and Vitamin D levels (R = -0.081, P = 0.002), whereas no significant correlation was found between age and Vitamin D levels (R = -0.025, P = 0.356). The findings suggest that gender may influence Vitamin D status, while age does not significantly impact deficiency levels. These results highlight the need for public health interventions focusing on dietary habits, sun exposure, and Vitamin D supplementation to mitigate deficiency risks, particularly among vulnerable populations.
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- References
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Ahmed Mohamed, A., Salah Ahmed, E. M., Farag, Y. M. K., Bedair, N. I., Nassar, N. A., & Ghanem, A. I. M. (2021). Dose-response association between vitamin D deficiency and atopic dermatitis in children, and effect modification by gender: A case-control study. Journal of Dermatological Treatment, 32(2), 174–179. https://doi.org/10.1080/09546634.2019.1643447 DOI: https://doi.org/10.1080/09546634.2019.1643447
Alqahtani, S. A. M. (2022, January 1). The Effect of Gender and Altitude on Vitamin D Status Among Saudi Population: A Cross Sectional Study. | EBSCOhost. https://doi.org/10.37290/ctnr2641-452X.201-6 DOI: https://doi.org/10.37290/ctnr2641-452X.20:1-6
AlQuaiz, A. M., Kazi, A., Fouda, M., & Alyousefi, N. (2018). Age and gender differences in the prevalence and correlates of vitamin D deficiency. Archives of Osteoporosis, 13(1), 49. https://doi.org/10.1007/s11657-018-0461-5 DOI: https://doi.org/10.1007/s11657-018-0461-5
Ambagaspitiya, S. S., Appuhamillage, G. A., & Wimalawansa, S. J. (2025). Impact of Vitamin D on Skin Aging, and Age-Related Dermatological Conditions. Frontiers in Bioscience-Landmark, 30(1), Article 1. https://doi.org/10.31083/FBL25463 DOI: https://doi.org/10.31083/FBL25463
Bayram, E., Ayan, D., Balcı, T., Zeybek Aydoğan, K., Inan, D. B., & Karabay, U. (2024). Vitamin D distribution by month, sex, and season in Turkey, Niğde province: A retrospective cohort study: D vitamin status in Niğde, Turkey. Journal of Surgery and Medicine, 8(3), 59–64. https://doi.org/10.28982/josam.7939 DOI: https://doi.org/10.28982/josam.7939
Bennouar, S., Bachir Cherif, A., Makrelouf, M., Ait Abdelkader, B., Taleb, A., & Abdi, S. (2022). Reconsidering vitamin D optimal values based on parathyroid hormone levels in a North Algerian cohort: Stratification by gender and season. Archives of Osteoporosis, 17(1), 100. https://doi.org/10.1007/s11657-022-01137-2 DOI: https://doi.org/10.1007/s11657-022-01137-2
Câmara, A. B., & Brandão, I. A. (2019). The relationship between vitamin D deficiency and oxidative stress can be independent of age and gender. International Journal for Vitamin and Nutrition Research. https://econtent.hogrefe.com/doi/10.1024/0300-9831/a000614
Chen, F., Wang, X., Wang, S., Zhao, X., Cheng, Y., & Wang, X. (2024). Association Between Serum Vitamin D Levels and Biological Aging Acceleration: Evidence from NHANES 2017-2018. Research Square. https://doi.org/10.21203/rs.3.rs-4464940/v1 DOI: https://doi.org/10.21203/rs.3.rs-4464940/v1
Eljamay, S., Alghzali, M., & Edalal, H. (2022). Incident Of Vitamin D Deficiency In Derna Citylibya. The Journal of Clinical Endocrinology and Metabolism, Vol (3), 1–15. https://doi.org/10.37191/Mapsci-2582-7960-3(1)-020 DOI: https://doi.org/10.37191/Mapsci-2582-7960-3(1)-020
Galeazzi, T., Quattrini, S., Pjetraj, D., Gatti, S., Monachesi, C., Franceschini, E., Marinelli, L., Catassi, G. N., Lionetti, E., & Catassi, C. (2023). Vitamin D status in healthy Italian school-age children: A single-center cross-sectional study. Italian Journal of Pediatrics, 49(1), 27. https://doi.org/10.1186/s13052-023-01422-x DOI: https://doi.org/10.1186/s13052-023-01422-x
Getachew, B., & Tizabi, Y. (2021). Vitamin D and COVID-19: Role of ACE2, age, gender, and ethnicity. Journal of Medical Virology, 93(9), 5285–5294. https://doi.org/10.1002/jmv.27075 DOI: https://doi.org/10.1002/jmv.27075
Minter, M., Augustin, H., van Odijk, J., & Vanfleteren, L. E. G. W. (2023). Gender Differences in Vitamin D Status and Determinants of Vitamin D Insufficiency in Patients with Chronic Obstructive Pulmonary Disease. Nutrients, 15(2), Article 2. https://doi.org/10.3390/nu15020426 DOI: https://doi.org/10.3390/nu15020426
Mo, H., Zhang, J., Huo, C., Zhang, M., Xiao, J., Peng, J., Wang, G., Wang, C., & Li, Y. (2023). The association of vitamin D deficiency, age and depression in US adults: A cross-sectional analysis. BMC Psychiatry, 23(1), 534. https://doi.org/10.1186/s12888-023-04685-0 DOI: https://doi.org/10.1186/s12888-023-04685-0
Murdaca, G., Tagliafico, L., Page, E., Paladin, F., & Gangemi, S. (2024). Gender Differences in the Interplay between Vitamin D and Microbiota in Allergic and Autoimmune Diseases. Biomedicines, 12(5), Article 5. https://doi.org/10.3390/biomedicines12051023 DOI: https://doi.org/10.3390/biomedicines12051023
Oh, S., Chun, S., Hwang, S., Kim, J., Cho, Y., Lee, J., Kwack, K., & Choi, S.-W. (2021). Vitamin D and Exercise Are Major Determinants of Natural Killer Cell Activity, Which Is Age- and Gender-Specific. Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.594356 DOI: https://doi.org/10.3389/fimmu.2021.594356
Paker, N., Yavuz Mollavelioglu, T., Bugdaycı, D., Ones, K., Bardak, A. N., Karacan, I., Yıkıcı, I., & Kesiktas, F. N. (2023). Vitamin D levels in children with cerebral palsy. Journal of Pediatric Rehabilitation Medicine, 16(1), 163–169. https://doi.org/10.3233/PRM-190622 DOI: https://doi.org/10.3233/PRM-190622
Trifan, D. F., Tirla, A. G., Mos, C., Danciu, A., Bodog, F., Manole, F., & Ghitea, T. C. (2023). Involvement of Vitamin D3 in the Aging Process According to Sex. Cosmetics, 10(4), Article 4. https://doi.org/10.3390/cosmetics10040114 DOI: https://doi.org/10.3390/cosmetics10040114
Trollfors, B. (2022). Ethnicity, gender and seasonal variations all play a role in vitamin D deficiency. Acta Paediatrica, 111(8), 1596–1602. https://doi.org/10.1111/apa.16372 DOI: https://doi.org/10.1111/apa.16372
Veysel Tahiroğlu, N. Ö. A. (2023, April 24). Change of Vitamin D Levels According to Age, Gender and Seasons in Şırnak Province [Text]. Turkish Journal of Osteoporosis. https://doi.org/10.4274/tod.galenos.2022.48303 DOI: https://doi.org/10.4274/tod.galenos.2022.48303
Zaher Khazaei, Salman Khazaei, Sara Beigrezaei, Hamid Nasri, (2018), Vitamin D deficiency in healthy people and its relationship with gender and age, Journal of Parathyroid Disease 2018,6(1),16–18, DOI: 10.15171/jpd.2018.06 DOI: https://doi.org/10.15171/jpd.2018.06
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- 2025-02-18
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- Vol. 3 No. 2 (2025)
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- Original Articles
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Copyright (c) 2025 Fathia Eessa faid, Aziza M Agwaida Alsheekh, Maryam Fawzi Abais, Salwa Muftah Eljamay (Author)

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