EVANS SYNDROME TRIGGERED BY COVID-19 INFECTION
- Authors
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Rudhuway Abdulqadir Mtawil
Physiology Department, Tobruk Medical University, TobrukAuthor
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- Keywords:
- Evans syndrome, Autoimmune Cytopenia, COVID-19, Autoimmune Hemolytic Anemia, Immune Thrombocytopenia, Hematology
- Abstract
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Evans syndrome is a rare autoimmune disorder characterized by the coexistence of autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia (ITP). The pathogenesis involves immune dysregulation leading to autoantibody-mediated destruction of multiple blood cell lineages. We report the case of a 40-year-old female presenting with jaundice, pancytopenia, hemodynamic instability, and serologically confirmed Evans syndrome associated with acute COVID-19 infection. The patient showed elevated AST and ALT, complete recovery after corticosteroid therapy, and has remained in remission for two years under regular follow-up.
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- References
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Aladily TN, Salama A. Autoimmune cytopenias in the context of COVID-19: mechanisms and management. Front Immunol. 2021;12:758514.
Audia S, Mahévas M, Ouandji S, et al. Evans’ syndrome: from pathophysiology to treatment. Autoimmun Rev. 2022;21(1):103039.
.Evans RS, Takahashi K, Duane RT, Payne R, Liu C. Primary thrombocytopenic purpura and acquired hemolytic anemia: evidence for a common etiology. Arch Intern Med. 1951;87(1):48–65.
Godeau B, Caulier MT, Decuypere L, et al. Evans syndrome in adults: clinical presentation and outcome. QJM. 2002;95(9):597–607.
Khelif A, Beyaert R, Michel M. Recent advances in the understanding and management of Evans syndrome. Br J Haematol. 2023;203(4):457–470.
Michel M, Chanet V, Dechartres A, et al. The spectrum of Evans syndrome in adults: new insight into the disease based on the analysis of 68 cases. Blood. 2009;114(15):3167–3172.
Taherifard E, et al. COVID-19 associated Evans syndrome: A case report and review of the literature. Clin Case Rep. 2022;10(7):e06111.
Jaime-Pérez JC, Aguilar-Calderón PE, Salazar-Cavazos L, Gómez-Almaguer D. Evans syndrome: clinical perspectives, biological insights and treatment modalities. J Blood Med. 2018;9:171–184.
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- Published
- 2025-11-12
- Issue
- Vol. 5 No. 1 (2025)
- Section
- Case Study
- License
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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