Role of Cinnamon Extract in the Protection Against Co-amoxiclav-Induced Nephrotoxicity Damage in Male Albino Rats

Aesha  Salem Abdulmawla Masud; Khaled  Salem Abdulmawla Masud; Khansa  Mohammad Khalil Elsheikh; Osama  M El-barasi; Faried  Abdel-Kader E. Hemieda; Wafaa  M. El-Kholy

doi:10.71147/wqsvre11

Authors

Aesha Salem Abdulmawla Masud Laboratory of Medicine, Collage of Medical Technology- Darna, Libya Author
Khaled Salem Abdulmawla Masud Zoology Department, Science Faculty, Derna University, Derna, Libya Author
Khansa Mohammad Khalil Elsheikh Biomedical Sciences Microbiology Department Faculty of Medicine Benghazi University, Libya Author
Osama M El-barasi Zoology Department, Science Faculty, Derna University, Derna, Libya Author
Faried Abdel-Kader E. Hemieda Zoology Department, Faculty of Science Mansoura University, Egypt Author
Wafaa M. El-Kholy Zoology Department, Faculty of Science Mansoura University, Egypt Author

DOI:

https://doi.org/10.71147/wqsvre11

Keywords:

Co-amoxiclav, Cinnamon, Renal, 0xidative stress, Antioxidants

Abstract

Co-amoxiclav (CA), which is effectively used in the treatment of several number of bacterial infections, may cause nephrotoxicity. Cinnamon extract contains natural products which showed antioxidant, anti-inflammatory and anti-bacterial properties. In the present study, two doses of CA, therapeutic (30 mg/kg) and double therapeutic (60 mg/kg), were orally given to rats alone or in combination with cinnamon (200 mg/kg) for 10 consecutive days, to test the potential protective impact of cinnamon extract against CA-induced nephrotoxicity. Obtained results showed significant increases in serum concentration of creatinine (Cr), urea (Ur) and uric acid (UA) in rats treated with CA. Renal contents of malondialdehyde (MDA), protein carbonyl (PC), hydrogen peroxide (H₂O₂) and nitric oxide (NO) were also markedly increased following administration of CA. On contrary, treatment with CA produced significant decreases in the renal levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GRd), glutathione-s-transferase (GST) and reduced glutathione (GSH). The drug was also found to induce up regulation of pro-apoptotic p53 and caspase-3 proteins expression, while it down regulated the expression of the anti-apoptotic protein Bcl-2 in the kidney of treated rats. CA-induced adverse effects in all investigated biochemical indices seemed to be dose-dependent. However, administration of cinnamon extract along with CA to rats reduced renal injury, oxidative stress and apoptosis caused by treatment with CA alone. It could be concluded that cinnamon extract may be useful in the protection against CA-induced renal damage in rats

Author Biographies

Aesha Salem Abdulmawla Masud , Laboratory of Medicine, Collage of Medical Technology- Darna, Libya

Laboratory of Medicine, Collage of Medical Technology- Darna, Libya
Khaled Salem Abdulmawla Masud , Zoology Department, Science Faculty, Derna University, Derna, Libya

Zoology Department, Science Faculty, Derna University, Derna, Libya
Khansa Mohammad Khalil Elsheikh, Biomedical Sciences Microbiology Department Faculty of Medicine Benghazi University, Libya

Biomedical Sciences Microbiology Department Faculty of Medicine Benghazi University, Libya
Osama M El-barasi, Zoology Department, Science Faculty, Derna University, Derna, Libya

Zoology Department, Science Faculty, Derna University, Derna, Libya
Faried Abdel-Kader E. Hemieda , Zoology Department, Faculty of Science Mansoura University, Egypt

Zoology Department, Faculty of Science Mansoura University, Egypt
Wafaa M. El-Kholy, Zoology Department, Faculty of Science Mansoura University, Egypt

Zoology Department, Faculty of Science Mansoura University, Egypt

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